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Drug Enforcement Administration

82 documents across 21 days of the archive, 7 of them final rules. The five most recent days are below.

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Comment deadlines and effective dates from anything this agency published in the archive, still ahead of 19 October 2026.

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as_of

  1. +2d Takes effect Schedules of Controlled Substances: Placement of Diphenidine in Schedule I Justice Department · Drug Enforcement Administration
  2. +4d Comments close Schedules of Controlled Substances: Placement of 4-Hydroxy-N,N-Diisopropyltryptamine (4-OH-DiPT), 5-Methoxy-alpha-Methyltryptamine (5-MeO-AMT), 5-Methoxy-N-Methyl-N-Isopropyltryptamine (5-MeO-MiPT), 5-Methoxy-N,N-Diethyltryptamine (5-MeO-DET), and N,N-Diisopropyltryptamine (DiPT) Into Schedule I Justice Department · Drug Enforcement Administration
  3. +7d Comments close Bulk Manufacturer of Controlled Substances Application: Kinetochem LLC Justice Department · Drug Enforcement Administration
  4. +7d Comments close Bulk Manufacturer of Controlled Substances Application: Chattem Chemicals Justice Department · Drug Enforcement Administration
  5. +7d Comments close Bulk Manufacturer of Controlled Substances Application: Scottsdale Research Institute SRI Montana Satellite Laboratory Justice Department · Drug Enforcement Administration
  6. +7d Comments close Bulk Manufacturer of Controlled Substances Application: Curia Missouri Inc. Justice Department · Drug Enforcement Administration
  7. +7d Comments close Bulk Manufacturer of Controlled Substances Application: Curia New York Inc Justice Department · Drug Enforcement Administration
  8. +7d Comments close Bulk Manufacturer of Controlled Substances Application: Biopharmaceutical Research Company Justice Department · Drug Enforcement Administration
  9. +7d Comments close Bulk Manufacturer of Controlled Substances Application: Cambrex Charles City Justice Department · Drug Enforcement Administration
  10. +7d Comments close Bulk Manufacturer of Controlled Substances Application: Chemtos, LLC Justice Department · Drug Enforcement Administration
  11. +7d Comments close Importer of Controlled Substances Application: Fisher Clinical Services, Inc. (I) Justice Department · Drug Enforcement Administration
  12. +7d Comments close Importer of Controlled Substances Application: Cambridge Isotope Laboratories, Inc. Justice Department · Drug Enforcement Administration
  13. +9d Comments close Importer of Controlled Substances Application: Benuvia Operations, LLC Justice Department · Drug Enforcement Administration
  14. +21d Comments close Bulk Manufacturer of Controlled Substances Application: Irvine Labs, Inc. Justice Department · Drug Enforcement Administration
  15. +21d Takes effect Schedules of Controlled Substances; Removal of Exemption Status for Inactive Butalbital Products Justice Department · Drug Enforcement Administration
  16. +25d Comments close Bulk Manufacturer of Controlled Substances Application: Cambrex High Point, Inc. Justice Department · Drug Enforcement Administration
  17. +30d Comments close Importer of Controlled Substances Application: Organic Standards Solutions International, LLC Justice Department · Drug Enforcement Administration
  18. +30d Comments close Importer of Controlled Substances Application: Groff NA Hemplex LLC Justice Department · Drug Enforcement Administration
  19. +30d Comments close Importer of Controlled Substances Application: National Center for Natural Products Research Justice Department · Drug Enforcement Administration
  20. +30d Comments close Importer of Controlled Substances Application: Groff Health Inc. Justice Department · Drug Enforcement Administration
  21. +30d Comments close Importer of Controlled Substances Application: DMS Pharmaceutical Group Justice Department · Drug Enforcement Administration
  22. +30d Comments close Importer of Controlled Substances Application: Halo Pharmaceutical Inc. Justice Department · Drug Enforcement Administration
  23. +35d Comments close Bulk Manufacturer of Controlled Substances Application: Cayman Chemical Company Justice Department · Drug Enforcement Administration
  24. +35d Comments close Bulk Manufacturer of Controlled Substances Application: Eli-Elsohly Laboratories Justice Department · Drug Enforcement Administration
  25. +39d Comments close Bulk Manufacturer of Controlled Substances Application: Irvine Labs, Inc. Justice Department · Drug Enforcement Administration
  26. +39d Comments close Bulk Manufacturer of Controlled Substances Application: Cargill, Incorporated Justice Department · Drug Enforcement Administration
  27. +42d Comments close Extension of Reexportation Period. Justice Department · Drug Enforcement Administration
  28. +60d Comments close Bulk Manufacturer of Controlled Substances Application: Janssen Pharmaceuticals, Inc. Justice Department · Drug Enforcement Administration
  29. +60d Comments close Bulk Manufacturer of Controlled Substances Application: Groff Health Inc Justice Department · Drug Enforcement Administration
  30. +60d Comments close Bulk Manufacturer of Controlled Substances Application: Scottsdale Research Institute Justice Department · Drug Enforcement Administration

2 more beyond these.

19 October 2026 11 documents

Machine-written from the fields above · claude-haiku-4-5-20251001

The Drug Enforcement Administration published eleven notices regarding applications for controlled substance importer and bulk manufacturer registrations and one decision and order.

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NoticeJustice DepartmentDrug Enforcement Administration

Bulk Manufacturer of Controlled Substances Application: National Center for Natural Products Research University of Mississippi/NCNPR

National Center for Natural Products Research University of Mississippi/NCNPR has applied to be registered as a bulk manufacturer of basic class(es) of controlled substance(s). Refer to Supplementary Information listed below for further drug information.

  • Comments close in 60 days

91 FR 66152FR Doc. 2026-21359official PDFfederalregister.gov

14 October 2026 3 documents

Machine-written from the fields above · claude-haiku-4-5-20251001

The DEA published two proposed rules to schedule hydroxymitragynine-related substances and one notice regarding a practitioner decision.

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Proposed RuleJustice DepartmentDrug Enforcement Administration

Schedules of Controlled Substances: Temporary Placement of 7- Hydroxymitragynine and Mitragynine Pseudoindoxyl Above a Specified Threshold in Schedule I

The Administrator of the Drug Enforcement Administration (DEA) is issuing this notice of intent to publish a temporary order to schedule 7-hydroxymitragynine and mitragynine pseudoindoxyl (including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible) when either substance alone, or their combined amount if both are present, is above a specified threshold, in schedule I of the Controlled Substances Act (CSA). Based on a different threshold provided by the Department of Health and Human Services (HHS) in July of 2025, DEA published a notice of intent to temporarily schedule 7-hydroxymitragynine above that lower threshold on July 7, 2026. Additionally, DEA published a temporary order placing mitragynine pseudoindoxyl without a threshold in schedule I of the CSA on August 26, 2026. On October 8, 2026, HHS sent a letter recommending that DEA place of the CSA 7-hydroxymitragynine and mitragynine pseudoindoxyl in schedule I when either substance alone, or their combined amount if both are present, is above a new specified threshold. Based on the October 8, 2026 letter, DEA is issuing this notice of intent. While the new threshold recommended by HHS would permit certain products to remain in the marketplace without being subject to schedule I controls, neither HHS nor DEA has made a finding that these substances are safe to use at below-threshold levels. When a temporary order is issued, it will impose the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis with, or possess) or propose to handle 7- hydroxymitragynine and/or mitragynine pseudoindoxyl above the specified threshold. In a separate document contained in this issue of the Federal Register, DEA is withdrawing the July 7, 2026 notice of intent related to 7-hydroxymitragynine. The August 26, 2026 temporary order placing mitragynine pseudoindoxyl in schedule I of the CSA without a threshold remains in effect until either it expires or the new temporary order is published and the previous order is withdrawn, whichever occurs first.

91 FR 65370FR Doc. 2026-20943official PDFfederalregister.gov

Proposed RuleJustice DepartmentDrug Enforcement Administration

Schedules of Controlled Substances: Temporary Placement of MGM-15 and MGM-16 in Schedule I

The Drug Enforcement Administration (DEA) is issuing this notice of intent to publish a temporary order to schedule two 7- hydroxymitragynine-related substances (MGM-15 and MGM-16), including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible, in schedule I of the Controlled Substances Act (CSA). On August 26, 2026, DEA published a temporary order placing mitragynine pseudoindoxyl, MGM-15, and MGM-16 in schedule I of the CSA. Today, DEA is providing notice of its intent to publish a new temporary order for MGM-15 and MGM-16 that will maintain the temporary placement of these substances in schedule I of the CSA without change. Separately in this Federal Register, DEA is publishing a notice of intent relating to mitragynine pseudoindoxyl, in response to a letter sent by the Department of Health and Human Services (HHS) dated October 6, 2026. HHS's letter related only to mitragynine pseudoindoxyl. Therefore, DEA is publishing this notice of intent only for the technical and procedural purpose of distinguishing MGM-15 and MGM-16 from mitragynine pseudoindoxyl. When issued, the temporary scheduling order addressing MGM-15 and MGM-16 will continue to impose the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis with, or possess) or propose to handle these two 7-hydroxymitragynine-related substances. The August 26, 2026 temporary order placing these substances in schedule I of the CSA remains in effect until either it expires or the new temporary order is published and the previous order is withdrawn, whichever occurs first.

91 FR 65381FR Doc. 2026-20942official PDFfederalregister.gov

9 October 2026 5 documents

Machine-written from the fields above · claude-haiku-4-5-20251001

The DEA published two rules removing exemption status for inactive butalbital products and correcting Schedule I placement language for O-desmethyltramadol, and three notices of decisions and orders.

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RuleJustice DepartmentDrug Enforcement Administration

Schedules of Controlled Substances; Removal of Exemption Status for Inactive Butalbital Products

The Drug Enforcement Administration (DEA) is revoking the exempted status for certain nonnarcotic prescription products that are currently on DEA's Table of Exempted Prescription Products, but whose National Drug Codes (NDC) are inactive because they are no longer available and/or the company that applied for the exemption no longer exists. These products will be removed from DEA's Table of Exempted Prescription Products and will no longer be considered exempt prescription products under the Controlled Substances Act. This action does not impact exempted prescription products with active NDC numbers.

  • Takes effect in 21 days

91 FR 64618FR Doc. 2026-20757official PDFfederalregister.gov

RuleJustice DepartmentDrug Enforcement Administration

Schedules of Controlled Substances: Placement of O-Desmethyltramadol in Schedule I; Correction

On August 12, 2026, the Drug Enforcement Administration (DEA) published a temporary order placing O-desmethyltramadol (other names: O-DSMT; desmetramadol; 3-[(1R,2R)-2-[(dimethylamino)methyl]-1- hydroxycyclohexyl]phenol), including its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers are possible, in schedule I of the Controlled Substances Act. DEA published this temporary order that specifically noted in the summary that the control of O-desmethyltramadol included its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers are possible, however inadvertently omitted the correct language that should have been included. This document corrects that error, adding the correct language.

  • Takes effect 10 days ago

91 FR 64617FR Doc. 2026-20748official PDFfederalregister.gov

7 October 2026 4 documents

Machine-written from the fields above · claude-haiku-4-5-20251001

The Drug Enforcement Administration published four notices on October 7, 2026, including decision and orders for Medpharm Research, Wellwise Pharmacy, and Arenbii Pharmacy.

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2 October 2026 2 documents

No sentence for this date — either it has not been generated yet, or it was withheld by the fidelity gate.

Earlier

16 further days of this agency's activity are in the long-form archive, oldest to newest, on one page.

Everything Drug Enforcement Administration has published, 2026-08-11 to 2026-10-19 →

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